Suc-YVAD-pNA

Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) [1].

Product Specifications

CAS Number

[208264-84-0]

UNSPSC

12352209

Target

Interleukin Related

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/suc-yvad-pna.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](NC(CCC(O)=O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(NC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O)=O

Molecular Formula

C31H38N6O12

Molecular Weight

686.67

References & Citations

[1]N Margolin, et al. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J Biol Chem. 1997 Mar 14;272 (11) :7223-8.