JAK2 JH2 binder-1

JAK2 JH2 binder-1 (compound 11) is a potent and selective JAK2 JH2 binder, with a Kd of 37.1 nM. JAK2 JH2 binder-1 has the potential for various myeloproliferative neoplasms research[1].

Product Specifications

CAS Number

[2923309-41-3]

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jak2-jh2-binder-1.html

Purity

95.40

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NC1=NC(NC2=CC=C(C=C2)S(=O)(N)=O)=NN1C(NC3=CC=C(C=C3)C4=CC(C(O)=O)=C(C=C4)OCC5=CC=CC=C5)=O

Molecular Formula

C29H25N7O6S

Molecular Weight

599.62

References & Citations

[1]Losi ME, et, al. Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. J Med Chem. 2022 Jun 23;65 (12) :8380-8400.