L759633
L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production[1][2].
Product Specifications
CAS Number
174627-50-0
UNSPSC
12352005
Hazard Statement
H225, H319, H336
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l759633.html
Concentration
26 mM * 100 μL in Methyl acetate
Purity
99.0
Solubility
10 mM in DMSO
Smiles
COC1=C2[C@@]3([H])[C@](CC=C(C)C3)([H])C(C)(C)OC2=CC(C(C)(C)CCCCCC)=C1
Molecular Formula
C26H40O2
Molecular Weight
384.59
Precautions
H225, H319, H336
References & Citations
[1]Ross RA, et, al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. Br J Pharmacol. 1999 Feb;126 (3) :665-72.|[2]Dhopeshwarkar A, et, al. Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway. J Pharmacol Exp Ther. 2016 Aug;358 (2) :342-51.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1; CB2
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