Sonolisib
Sonolisib (PX-866), an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ) ) . Antitumor activity[1][2].
Product Specifications
CAS Number
502632-66-8
Product Name Alternative
PX-866
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sonolisib.html
Purity
99.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C([C@@](CC2)([H])[C@@]3(C)C2=O)=C([C@H](OC(C)=O)C3)[C@]4(C)C(/C(C(O[C@@H]4COC)=O)=C\N(CC=C)CC=C)=C1O
Molecular Formula
C29H35NO8
Molecular Weight
525.59
Precautions
H302+H312+H332, H315, H319
References & Citations
[1]Ihle NT, et al. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growthfactor receptor inhibitor ZD1839 in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther. 2005 Sep;4 (9) :1349-57.|[2]Bowles DW, et al. A Randomized, Phase II Trial of C225 With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma. Clin Colorectal Cancer. 2016 Dec;15 (4) :337-344.e2.|[3]Sonolisib
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P120γ; PI3Kα; PI3Kδ
Available Sizes
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