XY028-140
Product Specifications
UNSPSC Description
XY028-140 is a PROTAC connected by ligands for Cereblon and CDK. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity in cancer cells[1].
Target Antigen
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xy028-140.html
Smiles
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NCC(N4CCN(CC4)C5=CN=C(NC6=NC(N(C7CCCC7)C(C(C(C)=O)=C8C)=O)=C8C=N6)C=C5)=O)=CC=C2
Molecular Weight
760.80
References & Citations
[1]Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1.|[2]Xuewei Wu, et al. Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders. Nat Cancer 2, 429-443 (2021).
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138946/XY028-140-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138946/XY028-140-SDS-MedChemExpress.pdf
CAS Number
2229974-83-6
Available Sizes
Curated Selection
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