Quetiapine-d4 (hydrochloride)
Quetiapine-d4 (hydrochloride) (ICI204636-d4 (hydrochloride) ) is deuterium labeled Quetiapine. Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].
Product Specifications
Product Name Alternative
ICI204636-d4 (hydrochloride)
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
OCCOC([2H])([2H])C([2H])([2H])N1CCN(C2=NC3=CC=CC=C3SC4=CC=CC=C24)CC1.Cl
Molecular Formula
C21H22D4ClN3O2S
Molecular Weight
423.99
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor
Frequently Asked Questions
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