Kaliotoxin

Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability[1][2].

Product Specifications

CAS Number

145199-73-1

UNSPSC

12352209

Hazard Statement

H301-H311-H330

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kaliotoxin.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]4CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]3CC7=CNC=N7)=O)NC4=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N8[C@H]5CCC8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C171H283N55O49S8

Molecular Weight

4149.94

Precautions

P260-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]M Crest, et al. Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca (2+) -activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom. J Biol Chem. 1992 Jan 25;267 (3) :1640-7. |[2]S Kourrich, et al. Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats. Behav Brain Res. 2001 Apr 8;120 (1) :35-46.