Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Secalciferol-d6

Secalciferol-d6 is the deuterium labeled Secalciferol. Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification[1][2].

Product Specifications

CAS Number

1440957-55-0

Product Name Alternative

(24R) -24,25-Dihydroxyvitamin D3-d6

UNSPSC

12352211

Target

Endogenous Metabolite; Isotope-Labeled Compounds; VD/VDR

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](\C(=C\C=C\3/C(=C)CC[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CC[C@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])O)O)C)[H])[H]

Molecular Formula

C27H38D6O3

Molecular Weight

422.68

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Yamamoto T, Ozono K, Shima M, et al. 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 1998 Oct 10;244 (1) :71-6.|[3]Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259 (3) :731-8.|[4]Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25 (OH) 2-vitamin D3 (rapid effects) and 24R,25 (OH) 2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197 (1-2) :1-13|[5]Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122 (4) :264-71.|[6]Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88 (1-2) :110-6.|[7]Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr Res. 1993 Jul;34 (1) :98-104.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CD19 (Ab-531) Antibody
8B0412-AAT 50 µg

CD19 (Ab-531) Antibody

Sign In for Pricing
View Details
CD3e, Mouse (145-2C11), CF640R conjugate, 0.1mg/mL
BNC402013-100 1x 100 µL

CD3e, Mouse (145-2C11), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
IFluor® 532 Styramide
45023-AAT 100 Slides

IFluor® 532 Styramide

Sign In for Pricing
View Details
Desmoglein 1 (DSG1) Human Gene Knockout Kit (CRISPR)
KN418157 1 Kit

Desmoglein 1 (DSG1) Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Frozen Tissue Blocks, Soft tissue
CB602761 1 Block

Frozen Tissue Blocks, Soft tissue

Sign In for Pricing
View Details
C3orf38 Recombinant Rabbit Monoclonal Antibody [JE64-28]
HA722360 100 µL

C3orf38 Recombinant Rabbit Monoclonal Antibody [JE64-28]

Sign In for Pricing
View Details