BAY 41-8543

BAY 41-8543 is an orally active, nitric oxide (NO) -independent stimulator of soluble guanylyl cyclase (sGC) . BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research[1].

Product Specifications

CAS Number

[256498-66-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bay-41-8543.html

Purity

99.94

Solubility

DMF : 16.67 mg/mL (ultrasonic) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 1 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC(N)=C1N5CCOCC5

Molecular Formula

C21H21FN8O

Molecular Weight

420.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Adeleke M Badejo Jr, et al. Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide. Am J Physiol Heart Circ Physiol.|[2]Johannes-Peter Stasch, et al. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. Br J Pharmacol. 2002 Jan;135 (2) :344-55.