ML133 HCl
Potassium channel Blocker- Neuroprotective
Product Specifications
Background
A potent and selective blocker of the inwardly rectifying Kir2 potassium channel, IC50s = 1.8, 2.8, 2,9, and 4.0 µM for Kir2.1, Kir2.6, Kir2.2, and Kir2.3, respectively (1). Intrathecal injection of ML133 attenuated the proliferation of microglia and neuropathic pain behaviors after nerve injury (2). ML133 inhibits microglial priming pointing to Kir2.1 channels as a new therapeutic target for neuronal damage (3). Moreover, treatment with ML133 one hour post-injury was sufficient to improve neuronal survival in a traumatic brain injury human organoid model (4).
CAS Number
1222781-70-5
Product Name Alternative
N-[ (4-Methoxyphenyl) methyl]-1-naphthalenemethanamine, hydrochloride
UNSPSC
41116105
Type
Blocker
Source
Synthetic
Field of Research
Neuroscience | Neurotransmission | Neurotransmitter Receptors | Ion Channels | Potassium Channels
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (32 mg/ml); or water (10 mg/ml, warm)
Molecular Formula
C19H19NO • HCl
Molecular Weight
313.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wang H.R. et al. 2011. ACS Chem. Biol. 6:845.
2. Gattlen C. et al. (2020) Glia 68:2119.
3. Spencer N.G. et al. (2016) PLoS One. 11(9):e0162497.
4. Lai J.D. et al. 2024. Cell Stem Cell 31:519.
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