What is the catalog number for ML133 HCl?

The catalog number for ML133 HCl is SIH-617-25MG.

What sizes are available for ML133 HCl?

ML133 HCl is available in the following size(s): 25 mg.

Is ML133 HCl in stock?

ML133 HCl is currently made to order / not held in immediate stock. Contact us for lead time.

ML133 HCl

Potassium channel Blocker- Neuroprotective

Product Specifications

Background

A potent and selective blocker of the inwardly rectifying Kir2 potassium channel, IC50s = 1.8, 2.8, 2,9, and 4.0 µM for Kir2.1, Kir2.6, Kir2.2, and Kir2.3, respectively (1). Intrathecal injection of ML133 attenuated the proliferation of microglia and neuropathic pain behaviors after nerve injury (2). ML133 inhibits microglial priming pointing to Kir2.1 channels as a new therapeutic target for neuronal damage (3). Moreover, treatment with ML133 one hour post-injury was sufficient to improve neuronal survival in a traumatic brain injury human organoid model (4).

CAS Number

1222781-70-5

Product Name Alternative

N-[ (4-Methoxyphenyl) methyl]-1-naphthalenemethanamine, hydrochloride

UNSPSC

41116105

Type

Blocker

Source

Synthetic

Field of Research

Neuroscience | Neurotransmission | Neurotransmitter Receptors | Ion Channels | Potassium Channels

Purity

>98% (HPLC) ; NMR (Conforms)

Weight

0.005

Format

White powder

Solubility

May be dissolved in DMSO (32 mg/ml); or water (10 mg/ml, warm)

Molecular Formula

C19H19NO • HCl

Molecular Weight

313.8

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Wang H.R. et al. 2011. ACS Chem. Biol. 6:845. 2. Gattlen C. et al. (2020) Glia 68:2119. 3. Spencer N.G. et al. (2016) PLoS One. 11(9):e0162497. 4. Lai J.D. et al. 2024. Cell Stem Cell 31:519.