Cytokeratin 4 (KRT4) (KRT4/2804), CF488A conjugate, 0.1mg/mL
Cytokeratin 4 (KRT4) is an intermediate filament protein associated with Cytokeratin 13 (KRT13) . It is expressed in suprabasal cells of non-keratinized stratified squamous epithelium of esophagus, cornea, anus, larynx, pharynx and tongue. Decreased expression of KRT4 is associated with head and neck squamous carcinoma. It is helpful in differentiation of squamous cell carcinoma of esophagus origin from that of thyroid origin. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Specifications
CAS Number
9007-83-4
Synonyms
CK4; CYK4; Cytokeratin 4; Keratin 4; Keratin type II cytoskeletal 4; KRT4
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
KRT4
Gene ID
3851
NCBI Gene ID
654610; 706527
UniProt
P19013
Swiss Prot
P19013
Host
Mouse
Species Reactivity
Human
Reactivity
Cytokeratin 4
Immunogen
Recombinant fragment (around aa 181-292) of human KRT4 protein (exact sequence is proprietary)
Target Antigen
Cytokeratin 4
Clonality
Monoclonal
Clone
KRT4/2804
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, intracellular (verified) |IF (verified) |IHC, FFPE (verified)
Field of Research
Cancer, Cytoskeleton
Positive Control
HeLa, A549 or A431 cells. Skin, Cervix or Esophagus.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
67 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF488A
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