Cathepsin K (Marker of Tumor Invasiveness) (CTSK/2792), 0.2mg/mL
Cathepsin K is a lysosomal and secreted cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Specifications
Synonyms
Cathepsin K; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CTSK
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CTSK
Gene ID
1513
NCBI Gene ID
632466
UniProt
P43235
Swiss Prot
P43235
Host
Mouse
Species Reactivity
Human
Reactivity
Cathepsin K
Immunogen
Recombinant fragment of human Cathepsin K protein (around aa 163-274) (exact sequence is proprietary)
Target Antigen
Cathepsin K
Clonality
Monoclonal
Clone
CTSK/2792
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified)
Positive Control
Human liver or breast tissue (IHC).
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
39 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Product Datasheet
https://cdn.gentaur.com/products/37/7645344/datasheet/bnub2792-100.pdf
Product MSDS
https://cdn.gentaur.com/products/37/68dd0298061270361e100e5d/msds/bnub2792-100.pdf
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
CAS Number
9007-83-4
Conjugate
Purified, with BSA
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