Isosilybin A

Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity[1][2][3].

Product Specifications

CAS Number

[142796-21-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Androgen Receptor; Apoptosis; ERK; NF-κB; p38 MAPK; PPAR

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isosilybin-a.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@H](O)[C@@H](C2=CC=C(O[C@H](C3=CC=C(O)C(OC)=C3)[C@@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15

Molecular Formula

C25H22O10

Molecular Weight

482.44

Precautions

H302

References & Citations

[1]Wu CC, et al. Isosilybin A exhibits anti-inflammatory properties in rosacea by inhibiting MAPK pathway and M1 macrophage polarization. Int Immunopharmacol. 2024 Dec 25;143 (Pt 1) :113323. |[2]Pferschy-Wenzig EM, et al. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. J Nat Prod. 2014 Apr 25;77 (4) :842-7.|[3]Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49 (10) :902-12.