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FXR agonist 10

FXR agonist 10 (Compound 27) is an agonist for FXR with an EC50 of 14.26 μM. FXR agonist 10 upregulates the expression of SHP and BSEP proteins, downregulates the expression of NTCP and CYP7A1 proteins. FXR agonist 10 ameliorates the ANIT-induced cholestasis in mouse model[1].

Product Specifications

UNSPSC

12352005

Target

FXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fxr-agonist-10.html

Smiles

C[C@@H]1C[C@]2(O)C(C(C)(C)OO2)=C[C@]34[C@](O4)(C)CC[C@@]31[H]

Molecular Formula

C15H22O4

Molecular Weight

266.33

References & Citations

[1]Yao Z, et al., The discovery of a new potent FXR agonist based on natural product screening. Bioorg Chem. 2024 Feb;143:106979.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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