Geranial

Geranial ((E) -3,7-Dimethylocta-2,6-dienal) is a derivative of geraniol with anti-inflammatory activity. Geranial can inhibit the secretion of TNF-α and IL-6 in macrophages. Furthermore, Geranial also inhibits the secretion of IL-1β mediated by the NLRP-3 inflammasome[1][2].

Product Specifications

CAS Number

[141-27-5]

Product Name Alternative

(E) -3,7-Dimethylocta-2,6-dienal

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Interleukin Related; NOD-like Receptor (NLR) ; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/geranial.html

Purity

99.51

Smiles

C/C(C)=C\CC/C(C)=C/C=O

Molecular Formula

C10H16O

Molecular Weight

152.23

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Iijima Y, et al. Biosynthesis of geranial, a potent aroma compound in ginger rhizome (Zingiber officinale) : molecular cloning and characterization of geraniol dehydrogenase[J]. Plant Biotechnology, 2014, 31 (5) : 525-534.|[2]Liao P C, et al. Anti-inflammatory activity of neral and geranial isolated from fruits of Litsea cubeba Lour[J]. Journal of Functional Foods, 2015, 19: 248-258.