3-O-Methyldopa (monohydrate)
3-O-Methyldopa monohydrate (3-Methoxy-L-tyrosine monohydrate) is a significant metabolite of L-DOPA produced through the action of catechol O-methyltransferase (COMT) . Unlike its precursor, 3-O-Methyldopa does not serve as a substrate or inhibitor of L-amino acid decarboxylase activity. Additionally, the inhibition of COMT can amplify the anti-Parkinson effects of L-DOPA.
Product Specifications
CAS Number
[200630-46-2]
Product Name Alternative
3-Methoxy-L-tyrosine (monohydrate) ; 3-O-Methyl-L-DOPA (monohydrate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-o-methyldopa-monohydrate.html
Purity
99.16
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@H](CC1=CC=C(C(OC)=C1)O)N)O.O
Molecular Formula
C10H15NO5
Molecular Weight
229.23
Precautions
H302, H315, H319, H335
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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