PRMT5-IN-30

PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.33 μM and a Kd of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation[1].

Product Specifications

CAS Number

[330951-01-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prmt5-in-30.html

Purity

99.17

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C1(SCC(=O)NC2C=CC=CC=2C(OC)=O)NC2C(=CC=C(OC)C=2)N=1

Molecular Formula

C18H17N3O4S

Molecular Weight

371.41

Precautions

H315, H319, H320

References & Citations

[1]Ruifeng Mao, et al. Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem. 2017 Jul 27;60 (14) :6289-6304.