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Anti-p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker), CF594 conjugate

p40 (p63 delta) is a marker recently determined to be highly specific for squamous basal cells in the immunohistochemistry (IHC) application. The current more routinely recommended marker, p63, appears to have less specificity compared to p40, especially on squamous cell tumors. The ability to differentiate between lung adenocarcinoma vs. squamous cell carcinoma is difficult and has bearing on the different therapeutic avenues for each subtype treatment. p63 antibody's ability to distinguish between the tumor types appears to be inferior when compared to p40. The ability to utilize an antibody probe for p40 as a squamous cell marker bolsters its use for future sub-classification of lung cancers, especially by immunohistochemical techniques. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

deltaNp63; TP63

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TP63

Gene ID

8626

NCBI Gene ID

137569

UniProt

Q9H3D4

Cellular Locus

Nucleus

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant human p40 protein fragment

Target Antigen

p40

Clonality

Polyclonal

Isotype

IgG

Conjugation

CF594

Disease

Tumor

Source

Animal

Applications

IHC, FFPE (verified)

Validated Applications

IHC,FFPE

Positive Control

Human prostate or lung tissue (IHC).

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

40 kDa

Shipping Conditions

Room temperature

Storage Conditions

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/7640581/datasheet/bnc942314-100.pdf

Product MSDS

https://cdn.gentaur.com/products/37/7640581/msds/bnc942314-100.pdf

CAS Number

9007-83-4

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