Anti-p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker), CF594 conjugate
p40 (p63 delta) is a marker recently determined to be highly specific for squamous basal cells in the immunohistochemistry (IHC) application. The current more routinely recommended marker, p63, appears to have less specificity compared to p40, especially on squamous cell tumors. The ability to differentiate between lung adenocarcinoma vs. squamous cell carcinoma is difficult and has bearing on the different therapeutic avenues for each subtype treatment. p63 antibody's ability to distinguish between the tumor types appears to be inferior when compared to p40. The ability to utilize an antibody probe for p40 as a squamous cell marker bolsters its use for future sub-classification of lung cancers, especially by immunohistochemical techniques. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Specifications
Synonyms
deltaNp63; TP63
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
TP63
Gene ID
8626
NCBI Gene ID
137569
UniProt
Q9H3D4
Cellular Locus
Nucleus
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant human p40 protein fragment
Target Antigen
p40
Clonality
Polyclonal
Isotype
IgG
Conjugation
CF594
Disease
Tumor
Source
Animal
Applications
IHC, FFPE (verified)
Validated Applications
IHC,FFPE
Positive Control
Human prostate or lung tissue (IHC).
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
40 kDa
Shipping Conditions
Room temperature
Storage Conditions
4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
2 years
Product Datasheet
https://cdn.gentaur.com/products/37/7640581/datasheet/bnc942314-100.pdf
Product MSDS
https://cdn.gentaur.com/products/37/7640581/msds/bnc942314-100.pdf
CAS Number
9007-83-4
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