Integrin beta 3 Antibody / ITGB3 / CD61
Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Product Specifications
UniProt
P05106
Host
Mouse
Immunogen
A recombinant human partial protein (amino acids 385-490) was used as the immunogen for this ITGB3 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
IHC-P
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the ITGB3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This ITGB3 antibody is available for research use only.
CAS Number
9007-83-4
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