Nitrocaramiphen (hydrochloride)

Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (Ki: 5.5 nM) . Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers[1][2][3].

Product Specifications

CAS Number

[98636-73-8]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nitrocaramiphen-hydrochloride.html

Purity

99.62

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(C1(C2=CC=C([N+]([O-])=O)C=C2)CCCC1)OCCN(CC)CC.[H]Cl

Molecular Formula

C18H27ClN2O4

Molecular Weight

370.87

References & Citations

[2]Hudkins RL, et al. Caramiphen, iodocaramiphen and nitrocaramiphen are potent, competitive, muscarinic M1 receptor-selective agents. Eur J Pharmacol. 1993 Feb 16;231 (3) :485-8.|[3]Naumenko NV, et al. [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2002 May;88 (5) :619-26.|[1]Hussain RI, et al. Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. Br J Pharmacol. 2009 Feb;156 (4) :575-86.