Galectin-3-IN-4
Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC50 values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC50 values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively[1].
Product Specifications
CAS Number
2496515-38-7
UNSPSC
12352005
Target
Galectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/galectin-3-in-4.html
Solubility
10 mM in DMSO
Smiles
CO[C@@H]1[C@@H](N2C=C(C3=C(C(F)=C(C=C3)Cl)F)N=N2)[C@H]([C@H](O[C@H]1C(N(C4=CC=C(N=CS5)C5=C4)C)=O)CO)O
Molecular Formula
C24H22ClF2N5O5S
Molecular Weight
565.98
References & Citations
[1]Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024 Mar 1;101:117638.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Galectin-1; Galectin-3
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