1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine (18:0-22:6 PE) is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.

Product Specifications

CAS Number

[96998-01-5]

Product Name Alternative

18:0-22:6 PE

UNSPSC

12352211

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine.html

Concentration

12.62 mM * 0.1 mL in Chloroform

Purity

99.0

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O[C@@H](COP(OCCN)(O)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

Molecular Formula

C45H78NO8P

Molecular Weight

792.08

References & Citations

[1]Juliano R L, et al. Liposomes as a drug delivery system for antisense oligonucleotides[J]. Antisense research and development, 1992, 2 (2) : 165-176.