(+) -Medicarpin
(+) -Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+) -Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action[1].
Product Specifications
CAS Number
[33983-39-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Estrogen Receptor/ERR
Type
Natural Products
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/medicarpin.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C([C@]2([H])[C@](C3=CC=C(OC)C=C3O2)([H])CO4)C4=C1
Molecular Formula
C16H14O4
Molecular Weight
270.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yang X, et al. Total Synthesis of (+) -Medicarpin. J Nat Prod. 2017 Dec 22;80 (12) :3284-3288.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ERβ
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