EM12-FS
EM12-FS is a cereblon (CRBN) ligand that binds CRBN at His353 and a molecular glue degrader of NTAQ1. EM12-FS has a human plasma half-life of 196 min[1].
Product Specifications
CAS Number
[2839138-44-0]
UNSPSC
12352005
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/em12-fs.html
Purity
98.4
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O
Molecular Formula
C13H11FN2O6S
Molecular Weight
342.30
References & Citations
[1]Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3 (9) :1105-1110.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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