SIRT3 activator 2
SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner[1].
Product Specifications
CAS Number
[3061491-60-6]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sirt3-activator-2.html
Purity
98.94
Solubility
DMSO : 4.93 mg/mL (ultrasonic)
Smiles
CC(CC1(C(N2CCC3=O)=O)CC2=O)(C(N1S(C4=CC(C(OCCCO3)=O)=CC=C4)(=O)=O)=O)C
Molecular Formula
C22H24N2O9S
Molecular Weight
492.50
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT3
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![N- (2,2-Dimethoxy-ethyl) -4- (4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl) -benzamide](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
N- (2,2-Dimethoxy-ethyl) -4- (4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl) -benzamide
![Human FSH Matched Antibody Pair Set [ABP-S-07445]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
KHNYN, CT (KHNYN, KIAA0323, Protein KHNYN, KH and NYN domain-containing protein) (AP) discontinued
