Amosulalol (hydrochloride)

Amosulalol (YM 09538) hydrochloride is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol hydrochloride exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol hydrochloride decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR) [1].

Product Specifications

CAS Number

[70958-86-0]

Product Name Alternative

YM 09538 (hydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/amosulalol-hydrochloride.html

Smiles

O=S(C1=CC(C(O)CNCCOC2=CC=CC=C2OC)=CC=C1C)(N)=O.Cl

Molecular Formula

C18H25ClN2O5S

Molecular Weight

416.92

References & Citations

[1]Honda K, et al. Autonomic and antihypertensive activity of oral amosulalol (YM-09538), a combined alpha- and beta-adrenoceptor blocking agent in conscious rats. Jpn J Pharmacol. 1985 May;38 (1) :31-41.