Human Tau-441 / 2N4R (P301L) Protein, His Tag

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.8 kDa. The protein migrates as 43-66 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Immobilized Human Tau-441 (P301L), His Tag (Cat. No. TAU-H5144) at 5 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 0.5-8 ng/mL (QC tested).