α4 integrin receptor antagonist 3
α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model[1].
Product Specifications
CAS Number
863226-74-8
UNSPSC
12352101
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/α4-integrin-receptor-antagonist-3.html
Smiles
COC1=C(C2=CC=C(C=C2)C[C@@H](C(O)=O)NC(C3=C(C=CC=C3Cl)Cl)=O)C(N(N=C1)CCO)=O
Molecular Formula
C23H21Cl2N3O6
Molecular Weight
506.34
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α4β1; α4β7
Frequently Asked Questions
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