FTO-IN-12

FTO-IN-12 (Compound 2) is an inhibitor of fat mass and obesity-related protein (FTO) . Kd and IC50 values are 185 nM and 1.46 μM, respectively. FTO-IN-12 can be used in the study of neurodegenerative diseases[1].

Product Specifications

CAS Number

[955328-22-0]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Fat Mass and Obesity-associated Protein (FTO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fto-in-12.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=C(N)C2=CC=CC(Cl)=C2N=C1

Molecular Formula

C10H7ClN2O2

Molecular Weight

222.63

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Selberg S, et al. Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons. Int J Mol Sci. 2021 Apr 26;22 (9) :4537.