Fumagilin-105
Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that degrades MetAP2 via p62-mediated macroautophagy in a ubiquitination-independent manner. Fumagilin-105 can inhibit the migration of tumor cells and induce programmed cell death. Fumagilin-105 has anti-tumor activity. (p62-ZZ ligand ; target-binding ligand (HY-B0751) ; linker (HY-W245803) ).
Product Specifications
CAS Number
2410081-58-0
UNSPSC
12352005
Target
Autophagy; AUTOTACs; MetAP; p62
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fumagilin-105.html
Purity
97.34
Solubility
DMSO : 63 mg/mL (ultrasonic)
Smiles
C[C@]1([C@H](O1)C/C=C(C)\C)[C@]2([H])[C@]3(CC[C@H]([C@H]2OC)OC(/C=C/C=C/C=C/C=C/C(NCCOCCOCCNCC4=CC(OCC5=CC=CC=C5)=CC=C4)=O)=O)CO3
Molecular Formula
C46H60N2O9
Molecular Weight
784.98
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Ep-CAM / CD326 (323/A3), CF594 conjugate, 0.1mg/mL
PAX2 (Renal Cell & Ovarian Carcinoma Marker) (PAX2/1104), CF640R conjugate, 0.1mg/mL
TLE1 (Synovial Sarcoma Marker) (TLE1/2085), CF640R conjugate, 0.1mg/mL
