Thiacetazone
Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1].
Product Specifications
CAS Number
104-06-3
Product Name Alternative
Thioacetazone; Amithiozone
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thiacetazone.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(NC1=CC=C(/C=N/NC(N)=S)C=C1)=O
Molecular Formula
C10H12N4OS
Molecular Weight
236.29
Precautions
H302
References & Citations
[1]J L Stigliani, et al. New Insights Into the Chemical Behavior of S-oxide Derivatives of Thiocarbonyl-Containing Antitubercular Drugs and the Influence on Their Mechanisms of Action and Toxicity. Ann Pharm Fr. 2019 Mar;77 (2) :126-135.|[2] P Khanna, et al. Characteristics of a Cytosolic Arylacylamidase Metabolizing Thiacetazone. J Pharmacol Exp Ther. 1992 Sep;262 (3) :1225-31.|[3]Anuradha Alahari, et al. Thiacetazone, an Antitubercular Drug That Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria. PLoS One. 2007 Dec 19;2 (12) :e1343.|[4]C A Peloquin, et al. Pharmacokinetic Evaluation of Thiacetazone. Pharmacotherapy. Sep-Oct 1996;16 (5) :735-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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