Thiacetazone

Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1].

Product Specifications

CAS Number

[104-06-3]

Product Name Alternative

Thioacetazone; Amithiozone

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/thiacetazone.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(NC1=CC=C(/C=N/NC(N)=S)C=C1)=O

Molecular Formula

C10H12N4OS

Molecular Weight

236.29

Precautions

H302

References & Citations

[1]J L Stigliani, et al. New Insights Into the Chemical Behavior of S-oxide Derivatives of Thiocarbonyl-Containing Antitubercular Drugs and the Influence on Their Mechanisms of Action and Toxicity. Ann Pharm Fr. 2019 Mar;77 (2) :126-135.|[2] P Khanna, et al. Characteristics of a Cytosolic Arylacylamidase Metabolizing Thiacetazone. J Pharmacol Exp Ther. 1992 Sep;262 (3) :1225-31.|[3]Anuradha Alahari, et al. Thiacetazone, an Antitubercular Drug That Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria. PLoS One. 2007 Dec 19;2 (12) :e1343.|[4]C A Peloquin, et al. Pharmacokinetic Evaluation of Thiacetazone. Pharmacotherapy. Sep-Oct 1996;16 (5) :735-41.