Rabbit anti Human Lass2
Product Specifications
Background
LASS2, a Human homologue of the yeast longevity assurance gene LAG1 is highly expressed in liver and kidney as compared to the expression of the Human LAG1 homologue LAG1Hs-1. LASS2 is located on chromosome 1q11. The LASS2 protein interacts with several membrane-associated receptors or transporters. LASS2 protein inhibits the colony formation of Human hepatoma cells in vitro, which suggests that this gene may be involved in the regulation of cell growth.
Synonyms
LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 Protein, SP260
UniProt
Q96G23
Host
Rabbit
Species Reactivity
Human,Rat,Mouse
Conjugation
Affinity Purified
Type
Antigen Immunoaffinity Purified Polyclonal
Applications
WB
Field of Research
Lipid Mediators
Purification Method
Antigen Immunoaffiinity Purification
Assay Principle
Antibody can be used for Western blotting (1:400 starting dilution) and immunohistochemistry (10-15 µg/mL). Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
Lot specific, See vial
Form
Provided as a solution in Tris buffered saline with 0,08% sodium azide, 10mM MgCl2, 10mM ammonium sulfate, and 0,2% lactose.
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1: Becker I, Wang-Eckhardt L, Yaghootfam A, Gieselmann V, Eckhardt M.Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2.
Histochem Cell Biol. 2008 Feb;129(2):233-41. Epub 2007 Sep 28.
2: Wang X, Carré W, Saxton AM, Cogburn LA. Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken.
Cytogenet Genome Res. 2007;117(1-4):174-88.
3:Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of Human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in Human head and neck squamous cell carcinomas.
Mol Cancer Ther. 2007 Feb;6(2):712-22.
4: Yu Y, Lu H, Pan H, Ma JH, Ding ZJ, Li YY. Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p.
Microbiol Res. 2006;161(3):203-11. Epub 2005 Sep 22.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
CAS Number
9007-83-4
Curated Selection
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