(Rac) -Talinolol-d5
(Rac) -Talinolol-d5 is the racemate of Talinolol. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity[1][2][3].
Product Specifications
CAS Number
1215343-94-4
UNSPSC
12352005
Target
Adrenergic Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O(C(C(C(NC(C)(C)C)([2H])[2H])(O)[2H])([2H])[2H])C1=CC=C(NC(NC2CCCCC2)=O)C=C1
Molecular Formula
C₂₀H₂₈D₅N₃O₃
Molecular Weight
368.53
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Assmann I. The actions of talinolol, a beta 1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction. Curr Med Res Opin. 1995;13 (6) :325-42.|[3]Kara ZP, et, al. The effects of P-glycoprotein inhibitor zosuquidar on the sex and time-dependent pharmacokinetics of parenterally administered talinolol in mice. Eur J Pharm Sci. 2021 Jan 1;156:105589. |[4]Shirasaka Y, et, al. Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. J Pharmacol Exp Ther. 2010 Jan;332 (1) :181-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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