PHA-680632

PHA-680632 is an aurora kinase inhibitor with IC50s of 27, 135 and 120 nM for aurora A, B and C, respectively.

Product Specifications

CAS Number

[398493-79-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PHA-680632.html

Purity

98.07

Solubility

DMSO : ≥ 30 mg/mL

Smiles

O=C(N1CC2=C(NN=C2NC(C3=CC=C(N4CCN(C)CC4)C=C3)=O)C1)NC5=C(C=CC=C5CC)CC

Molecular Formula

C28H35N7O2

Molecular Weight

501.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Soncini C, et al. PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity. Clin Cancer Res. 2006 Jul 1;12 (13) :4080-9.|[2]Tao Y, et al. Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Br J Cancer. 2007 Dec 17;97 (12) :1664-72.