DHFR-IN-20
DHFR-IN-20 (Compound LA1) is a Plasmodium falciparum dihydrofolate reductase (DHFR) inhibitor, with Kis of 0.16, 0.30, 6.6 nM for PfDHFR-WT, PfDHFR-QM, HsDHFR. DHFR-IN-20 has antimalarial activities (IC50: 1.4 nM and 1.6 μM for P. falciparum carrying the wild-type (TM4/8.2) and the quadruple mutant (V1/S) PfDHFR enzyme[1].
Product Specifications
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR) ; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-20.html
Smiles
O=C1OCC/C1=C\C2=CC=CC=C2OCCCOC3=C(CC)N=C(N)N=C3N.Cl
Molecular Formula
C20H25ClN4O4
Molecular Weight
420.89
References & Citations
[1]Decharuangsilp S, et al. Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors. Bioorg Chem. 2024 Sep 3;153:107789.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1412860 Inquire
Recombinant Lactobacillus salivarius DNA mismatch repair protein MutS (mutS), partial
Sign In for Pricing
View Details 