Flurochloridone

Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells[1][2].

Product Specifications

CAS Number

[61213-25-0]

Product Name Alternative

R-40244

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/flurochloridone.html

Purity

99.61

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=C1N(CC(C1Cl)CCl)C2=CC=CC(C(F)(F)F)=C2

Molecular Formula

C12H10Cl2F3NO

Molecular Weight

312.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang F, et al. Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2α-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells. Int J Environ Res Public Health. 2022 Apr 11;19 (8) :4564. |[2]Nikoloff N, et al. Flurochloridone-based herbicides induced genotoxicity effects on Rhinella arenarum tadpoles (Anura: Bufonidae) . Ecotoxicol Environ Saf. 2014 Feb;100:275-81.