Ru-Poma
Ru-Poma is a Ru (II) -based photosensitizer, which attenuates Cisplatin -resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ru-poma.html
Smiles
O=C1N(C(C2=C1C(NCCCOC3=CC=C(C4=NC5=C(C6=CC=C[N]7=C6C8=C5C=CC=[N]8[Ru+2]79([N]%10=CC=C(C(C=C%11)=C%10%12)C%13=CC=CC=C%13)([N]%14=CC=C(C%15=C%14C%16=[N]9C=CC(C%17=CC=CC=C%17)=C%16C=C%15)C%18=CC=CC=C%18)[N]%19=C%12C%11=C(C=C%19)C%20=CC=CC=C%20)N4C%21=CC=CC=C%21)C=C3)=CC=C2)=O)C%22CCC(NC%22=O)=O.O.O.O.O.O.O.[Cl-].[Cl-].O
Molecular Formula
C89H75Cl2N11O11Ru.7H2O
Molecular Weight
1664.61
References & Citations
[1]Lin X, et al., Two-Photon Photodegradation of E3 Ubiquitin Ligase Cereblon by a Ru (II) Complex: Inducing Ferroptosis in Cisplatin-Resistant Tumor Cells. J Med Chem. 2024 May 23;67 (10) :8372-8382.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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