Ru-Poma

Ru-Poma is a Ru (II) -based photosensitizer, which attenuates Cisplatin (HY-17394) -resistant tumor through photodynamic therapy (PDT) . Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Ligands for E3 Ligase

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ru-poma.html

Smiles

O=C1N(C(C2=C1C(NCCCOC3=CC=C(C4=NC5=C(C6=CC=C[N]7=C6C8=C5C=CC=[N]8[Ru+2]79([N]%10=CC=C(C(C=C%11)=C%10%12)C%13=CC=CC=C%13)([N]%14=CC=C(C%15=C%14C%16=[N]9C=CC(C%17=CC=CC=C%17)=C%16C=C%15)C%18=CC=CC=C%18)[N]%19=C%12C%11=C(C=C%19)C%20=CC=CC=C%20)N4C%21=CC=CC=C%21)C=C3)=CC=C2)=O)C%22CCC(NC%22=O)=O.O.O.O.O.O.O.[Cl-].[Cl-].O

Molecular Formula

C89H75Cl2N11O11Ru.7H2O

Molecular Weight

1664.61

References & Citations

[1]Lin X, et al., Two-Photon Photodegradation of E3 Ubiquitin Ligase Cereblon by a Ru (II) Complex: Inducing Ferroptosis in Cisplatin-Resistant Tumor Cells. J Med Chem. 2024 May 23;67 (10) :8372-8382.