(R) -PF-06256142
(R) -PF-06256142 is the R enantiomer of PF-06256142 with low active. PF-06256142 is a potent and selective orthosteric D1 receptor agonist that can reduce receptor desensitization relative to dopamine and other catechol-containing agonists[1].
Product Specifications
CAS Number
[1609583-15-4]
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-pf-06256142.html
Purity
99.59
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC1=CC(OC2=C(C=CO3)C3=CC=N2)=CC=[C@]1[C@]4=C(C)N=CC5=NC=CN54
Molecular Formula
C21H16N4O2
Molecular Weight
356.38
References & Citations
[1]Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018;61 (24) :11384-11397.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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