Recombinant Human SERPINH1
Recombinant Human SERPINH1
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Hsp47
Gene Name
SERPINH1
UniProt
P50454
Cellular Locus
Endoplasmic reticulum lumen.
Reactivity
Human
Target Antigen
Serpin H1
Target
SERPINH1
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.
Specificity
SERPINH1
Formulation
Sterile-filtered colorless solution (1mg/ml) in 20mM Tris-HCl, pH 8.0, and 10% glycerol.
Buffer pH
pH 8.0
Target Background
SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors whose expression is induced by heat shock. As a molecular chaperone, it localizes to the endoplasmic reticulum lumen and binds collagen, thus participating in the maturation of collagen molecules, facilitating the folding and assembly of procollagen molecules, retaining unfolded molecules within the ER, and assisting in the transport of correctly folded molecules from the ER to the Golgi apparatus. Autoantibodies to SERPINH1 have been found in cases of rheumatoid arthritis.
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