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(4-NH2) -Exatecan-d5

(4-NH2) -Exatecan-d5 is a deuterated labeled (4-NH2) -Exatecan[1]. (4-NH2) -Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2) -Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) [2].

Product Specifications

Product Name Alternative

AZ14170132-d5

UNSPSC

12352005

Hazard Statement

H301

Target

ADC Payload; Isotope-Labeled Compounds; Topoisomerase

Type

Isotope-Labeled Compounds

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.62

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)C([2H])([2H])C([2H])([2H])[2H])=O

Molecular Formula

C23H16D5N3O4

Molecular Weight

408.46

Precautions

H301

References & Citations

[1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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