(4-NH2)-Exatecan-d5
Product Specifications
UNSPSC Description
(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan[1]. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[2].
Target Antigen
ADC Cytotoxin; Isotope-Labeled Compounds; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)C([2H])([2H])C([2H])([2H])[2H])=O
Molecular Weight
408.46
References & Citations
[1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Shipping Conditions
Blue Ice
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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