PHCCC(4Me)
Product Specifications
Product Name Alternative
1,25-Dihydroxyvitamin D3,MC 903 (Standard); Calcipotriene (Standard)
UNSPSC Description
PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator[1].
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phccc-4me.html
Purity
99.99
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C=C1)C)C23CC2/C(C4=C(C=CC=C4)O3)=N\O
Molecular Weight
308.33
References & Citations
[1]Stephan Schann, et al. Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators. J Med Chem. 2010 Dec 23;53(24):8775-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114863/PHCCC-4Me-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114863/PHCCC-4Me-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1259532-01-8
Available Sizes
Curated Selection
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