PDL1 degrader-2
PD-L1 degrader-2 (Compound B3) is an orally active AUTAC degrader, that degrades PD-L1 through autophagy-lysosome pathway with a DC50 of 0.5 μM. PD-L1 degrader-2 exhibits inhibitory activity against PD-1/PD-L1 interaction with an IC50 of 22.8 nM. PD-L1 degrader-2 upregulates the expressions of Atg9b, Lamp1 and Mitf, and activates the autophagy lysosome system. PD-L1 degrader- exhibits antitumor efficacy in CT26 mouse model[1]. (Pink: autophagy-lysosome activator ; Black: linker (HY-W015088) ; Blue: PD-L1 ligand (HY-169365) )
Product Specifications
UNSPSC
12352211
Target
AUTACs; Autophagy; PD-1/PD-L1
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-pd-l1-degrader-3.html
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C2=NN=C(NC3=CC(CNCCOCCOCCOCCNCC4=CC=CC(NC5=NN=C(C6=CC=CC=C6)O5)=C4)=CC=C3)O2)C=CC=C1C7=CC=CC=C7
Molecular Formula
C45H48N8O5
Molecular Weight
780.91
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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