Piperin-d10

Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL[1][2][3][4].

Product Specifications

Product Name Alternative

Bioperine-d10; 1-Piperoylpiperidine-d10

UNSPSC

12352005

Target

Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; P-glycoprotein

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(N1C([2H])(C([2H])(C([2H])(C([2H])(C1([2H])[2H])[2H])[2H])[2H])[2H])/C=C/C=C/C2=CC=C3OCOC3=C2

Molecular Formula

C17H9D10NO3

Molecular Weight

295.40

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3 (1) :9. Epub 2015 Oct 29.|[3]Meghwal M, et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27 (8) :1121-30.|[4]Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.|[5]Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.