β-Spaglumic acid
β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 μM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus) . β-Spaglumic acid can be used in neuroprotection-related studies[1][2].
Product Specifications
CAS Number
4910-46-7
Product Name Alternative
β-NAAG; β-N-Acetylaspartylglutamic acid
UNSPSC
12352211
Target
Aminopeptidase; mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/β-spaglumic-acid.html
Purity
99.97
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(C)=O)=O
Molecular Formula
C11H16N2O8
Molecular Weight
304.25
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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