NCS-MP-NODA
NCS-MP-NODA (NODA-Bz-SCN) is a bifunctional chelator that can be used to bind to the labeled peptide DK222 with high specificity for PD-L1. The corresponding fluorinated radioactive is synthesized by the aluminum fluoride method, and NCS-MP-NODA targets DK222 to obtain the radioactive analog [18/19F]DK222. [18F]DK222 can quantify PD-L1 in vivo via PET tracking in xenograft models of multiple cancer types.
Product Specifications
CAS Number
[1374994-81-6]
Product Name Alternative
NODA-Bz-SCN
UNSPSC
12352203
Target
Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ncs-mp-noda.html
Smiles
O=C(CN1CCN(CCN(CC1)CC2=CC=C(C=C2)N=C=S)CC(O)=O)O
Molecular Formula
C18H24N4O4S
Molecular Weight
392.47
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
RDC Bifunctional Chelator
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