Cinchonine

Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].

Product Specifications

CAS Number

[118-10-5]

Product Name Alternative

(8R,9S) -Cinchonine; LA40221

UNSPSC

12352005

Hazard Statement

H302, H317, H402

Target

Apoptosis; Autophagy; Calcium Channel; Caspase; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/Cinchonine.html

Purity

99.71

Solubility

DMSO : 4.76 mg/mL (ultrasonic)

Smiles

O[C@@H](C1=CC=NC2=CC=CC=C12)[C@]3([H])[N@@]4C[C@H](C=C)[C@@H](CC4)C3

Molecular Formula

C19H22N2O

Molecular Weight

294.40

Precautions

H302, H317, H402

References & Citations

[3]Jin ZL, et al., Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15 (6) :5046-5050.|[4]Wang H, et al., Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. Biomed Pharmacother. 2023 Aug;164:114980.|[5]Jung SA, et al., Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Res. 2012;2012:541204.|[6]Jo YJ, et al., Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis. J Cell Physiol. 2021 Mar;236 (3) :1854-1865.|[7]Shah BH, et al., The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. Biochem Pharmacol. 1998 Oct 15;56 (8) :955-60.|[8]Rani R, et al., Intracellular ROS production and apoptotic effect of quinoline and isoquinoline alkaloids on the growth of Trypanosoma evansi. Acta Trop. 2023 Sep;245:106980.|[1]Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15 (6) :5046-5050.|[2]Qi Y, et al., Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. J Exp Clin Cancer Res. 2017 Feb 23;36 (1) :35.