HWY-289

HWY-289 is a semisynthetic protoberberine derivative, has broad-spectrum and potent activities against phytopathogenic fungi, particularly Botrytis cinerea (EC50 = 1.34 μg/mL) . HWY-289 changes the morphology of the mycelium and the internal structure of cells. HWY-289 reduces ATP content, ATPase activities, and key enzyme activities in the TCA cycle[1].

Product Specifications

CAS Number

[908001-51-4]

UNSPSC

12352005

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hwy-289.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C=CC2=C1C=[N+]3C(C4=CC5=C(OCO5)C=C4CC3)=C2CC6=CC=C(C(C)(C)C)C=C6.[Br-]

Molecular Formula

C31H32BrNO4

Molecular Weight

562.49

References & Citations

[1]An JX, et al. Antifungal Activity and Putative Mechanism of HWY-289, a Semisynthetic Protoberberine Derivative, against Botrytis cinerea. J Agric Food Chem. 2024 Apr 10;72 (14) :7716-7726.