MS7829

MS7829 is a cGAS inhibitor-based deubiquitinase-targeted chimera (DUBTAC), a targeted protein stabilization (TPS) technology. cGAS is a key component in the cGAS-STING pathway.[1].

Product Specifications

CAS Number

[3060519-67-4]

UNSPSC

12352211

Target

Cyclic GMP-AMP Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms7829.html

Smiles

ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CC(NCCCCCCCCCNC(CCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl

Molecular Formula

C44H57Cl2N9O6S

Molecular Weight

910.95

References & Citations

[1]Deng Z, et al. The First-In-Class Deubiquitinase-Targeting Chimera Stabilizes and Activates cGAS. Angew Chem Int Ed Engl. 2024 Aug 16:e202415168.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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